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Lyons S , Sharp C , LeBreton M , Djoko CF , Kiyang JA , Lankester F , Bibila TG , Tamoufé U , Fair J , Wolfe ND , Simmonds P . 2012. Species association of hepatitis B virus (HBV) in non-human apes; evidence for recombination between gorilla and chimpanzee variants. PLoS One , 7 (3), pp. e33430. | Show Abstract | Read more

Hepatitis B virus (HBV) infections are widely distributed in humans, infecting approximately one third of the world's population. HBV variants have also been detected and genetically characterised from Old World apes; Gorilla gorilla (gorilla), Pan troglodytes (chimpanzee), Pongo pygmaeus (orang-utan), Nomascus nastusus and Hylobates pileatus (gibbons) and from the New World monkey, Lagothrix lagotricha (woolly monkey). To investigate species-specificity and potential for cross species transmission of HBV between sympatric species of apes (such as gorillas and chimpanzees in Central Africa) or between humans and chimpanzees or gorillas, variants of HBV infecting captive wild-born non-human primates were genetically characterised. 9 of 62 chimpanzees (11.3%) and two from 11 gorillas (18%) were HBV-infected (15% combined frequency), while other Old world monkey species were negative. Complete genome sequences were obtained from six of the infected chimpanzee and both gorillas; those from P. t .ellioti grouped with previously characterised variants from this subspecies. However, variants recovered from P. t. troglodytes HBV variants also grouped within this clade, indicative of transmission between sub-species, forming a paraphyletic clade. The two gorilla viruses were phylogenetically distinct from chimpanzee and human variants although one showed evidence for a recombination event with a P.t.e.-derived HBV variant in the partial X and core gene region. Both of these observations provide evidence for circulation of HBV between different species and sub-species of non-human primates, a conclusion that differs from the hypothesis if of strict host specificity of HBV genotypes.

Lavoie M , Sharp CP , Pépin J , Pennington C , Foupouapouognigni Y , Pybus OG , Njouom R , Simmonds P . 2012. Human parvovirus 4 infection, Cameroon. Emerg Infect Dis , 18 (4), pp. 680-683. | Show Abstract | Read more

In a post hoc analysis of samples collected in 2009, we determined seroprevalence of parvovirus 4 (PARV4) among elderly Cameroonians. PARV4 seropositivity was associated with receipt of intravenous antimalarial drugs, intramuscular streptomycin, or an intramuscular contraceptive, but not hepatitis C virus seropositivity. Findings suggest parenteral acquisition of some PARV4 infections.

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A novel positive-sense, single-stranded RNA (+ssRNA) virus (Halastavi árva RNA virus, HalV; JN000306) with di-cistronic genome organization was serendipitously identified in intestinal contents of freshwater carps (Cyprinus carpio) fished by line-fishing from fishpond "Lőrinte halastó" located in Veszprém County, Hungary. The complete nucleotide (nt) sequence of the genomic RNA is 9565 nt in length and contains two long--non-in-frame--open reading frames (ORFs), which are separated by an intergenic region. The ORF1 (replicase) is preceded by an untranslated sequence of 827 nt, while an untranslated region of 139 nt follows the ORF2 (capsid proteins). The deduced amino acid (aa) sequences of the ORFs showed only low (less than 32%) and partial similarity to the non-structural (2C-like helicase, 3C-like cystein protease and 3D-like RNA dependent RNA polymerase) and structural proteins (VP2/VP4/VP3) of virus families in Picornavirales especially to members of the viruses with dicistronic genome. Halastavi árva RNA virus is present in intestinal contents of omnivorous freshwater carps but the origin and the host species of this virus remains unknown. The unique viral sequence and the actual position indicate that Halastavi árva RNA virus seems to be the first member of a new di-cistronic ssRNA virus. Further studies are required to investigate the specific host species (and spectrum), ecology and role of Halastavi árva RNA virus in the nature.

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I would pack up and visit my sister in Seoul Korea!

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Hi Jean!

With the baby ( who is already a year old) we would love to go to Maine, we’ve never been there. While the baby is still sleeping, I’d watch the sun rise over the ocean, listen to some tunes, and recharge.

----- Rachel 26.11.10 03:17

It’s freaking cold here in cologne so I’d go anywhere warm. Bangkok would be really nice.

----- Thu 26.11.10 03:05

Lapland - to hand deliver Santa my shortened Christmas list (minus shades, bags, headphones, moleskins).

----- Willy J 26.11.10 02:56

Detroit…

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go visit wejetset and see the ruckus!

----- hiroki nishiyama 26.11.10 02:55

I would stuff with duffle with diapers and take my daughter to visit her Oma and Opa in Edmonton, Alberta Canada. You really haven’t lived until you’ve experienced -35 as a daytime high, West Edmonton Mall and an Edmonton Oilers hockey game at the Northlands Coliseum. E-town is a 9-hour flight from where we live, so the Moleskin notebooks would make perfect doodle pads. And once we’re there, the Summer Safari shades would be just the thing for protecting against snow glare. Great prize pack, NOTCOT! Who says you can’t be a mom AND stylish at the same time, eh?

----- Jessica 26.11.10 02:53

I’d pack my snorkel and head to Cozumel!

----- Nat G 26.11.10 02:51

I’d go to London, because every time I get there it feels like I’m returning home, and every time I’m away it feels like I am missing out on something. I live in Denmark, but have fallen so much in love with London! I cannot wait to go there again!

----- Camilla 26.11.10 02:49

I would hop on the train and go one stop, it doesn’t matter where that would be. It seems I always travel great distances, but never explore home. Maybe it’s time to be a tourist in my own town :)

----- alex 26.11.10 02:47

I think I’d have a round the world flight and finally get round to having a drink with all my friends in the finest bars! Well, it is friday!

----- Benjamin 26.11.10 02:44

I would fly first class from Burbank to LAX (I can make it happen) and hitch a ride to NOTCOT headquarters, wherever that sleek little younghip-white-brick office space or oh-so-decked-out-apartment living room may be, and have a stern god damn word with Jean Aw herself about this little giveaway you just put me through.

And that word would be thanx. Trueswear.

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